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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TSC2 All Species: 15.76
Human Site: S1274 Identified Species: 34.67
UniProt: P49815 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49815 NP_000539.2 1807 200608 S1274 P R S N T V A S F S S L Y Q S
Chimpanzee Pan troglodytes XP_523477 1803 200189 L1274 A V A S F S S L Y Q S S C Q G
Rhesus Macaque Macaca mulatta XP_001083256 1807 200600 S1274 P R S N T V A S F S S L Y Q S
Dog Lupus familis XP_852047 1813 201226 S1274 P R S N T V A S F S S L Y Q S
Cat Felis silvestris
Mouse Mus musculus Q61037 1814 202053 F1274 R S N T V A S F S S L Y Q P S
Rat Rattus norvegicus P49816 1809 201259 S1274 P R S N T V A S F S S L Y Q P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516748 947 107028 E450 Q N L Q L L M E R F F R N E P
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_695912 1128 123244 M631 M E E S G R S M A S V S P A E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524177 1847 204101 S1345 S S P E M S S S W R Q S F L T
Honey Bee Apis mellifera XP_395739 1813 206229 G1277 S L E S L E D G E D D L R R S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786931 1947 217345 T1374 D S L S F P R T E M G L S P M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97.9 91.2 N.A. 88.9 91 N.A. 44.1 N.A. N.A. 35.8 N.A. 29.8 38.2 N.A. 31.1
Protein Similarity: 100 99 99 94.6 N.A. 92.2 93.9 N.A. 48.3 N.A. N.A. 44.3 N.A. 49.7 58.6 N.A. 48.9
P-Site Identity: 100 13.3 100 100 N.A. 13.3 93.3 N.A. 0 N.A. N.A. 6.6 N.A. 6.6 13.3 N.A. 6.6
P-Site Similarity: 100 40 100 100 N.A. 26.6 93.3 N.A. 13.3 N.A. N.A. 20 N.A. 33.3 26.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 0 0 10 37 0 10 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 10 0 0 0 0 0 10 0 0 10 10 0 0 0 0 % D
% Glu: 0 10 19 10 0 10 0 10 19 0 0 0 0 10 10 % E
% Phe: 0 0 0 0 19 0 0 10 37 10 10 0 10 0 0 % F
% Gly: 0 0 0 0 10 0 0 10 0 0 10 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 10 19 0 19 10 0 10 0 0 10 55 0 10 0 % L
% Met: 10 0 0 0 10 0 10 10 0 10 0 0 0 0 10 % M
% Asn: 0 10 10 37 0 0 0 0 0 0 0 0 10 0 0 % N
% Pro: 37 0 10 0 0 10 0 0 0 0 0 0 10 19 19 % P
% Gln: 10 0 0 10 0 0 0 0 0 10 10 0 10 46 0 % Q
% Arg: 10 37 0 0 0 10 10 0 10 10 0 10 10 10 0 % R
% Ser: 19 28 37 37 0 19 37 46 10 55 46 28 10 0 46 % S
% Thr: 0 0 0 10 37 0 0 10 0 0 0 0 0 0 10 % T
% Val: 0 10 0 0 10 37 0 0 0 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 10 37 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _